Systemic & Digestive Enzymes for Candida » The Candida Diet


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Last updated January 27, 2022 by Lisa Richards, CNC

When fighting a Candida overgrowth, one of the biggest problems that your immune system faces is biofilms.

A biofilm is a protective matrix created by organisms like Candida albicans. Pathogenic organisms like Candida use biofilms to hide from your immune system.

Biofilms can be tough to break down, even with our recommended combination of probiotics and antifungals. This is especially true for longer-term cases of Candida.

If you can’t break down that biofilm, fighting Candida becomes much more difficult.

Enzymes are a tool that can help to break down those Candida biofilms more quickly.

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SerraDefend is the first formula that contains 9 of these biofilm-busting enzymes. We chose them for their ability to disrupt biofilms and fight Candida overgrowth. Let’s take a closer look!

The Best Enzymes For Candida

There are two sets of enzymes that are particularly helpful for Candida.

The first is systemic enzymes. These enzymes don’t just help with digestion; they also assist with other functions around your body. They include Serrapeptase and Nattokinase.

The second is digestive enzymes. These include protease, amylase, and cellulase. There are some digestive enzymes, like chitosanase and beta-glucanase, that can break down yeast cell walls and biofilms.


This is a proteolytic, systemic enzyme that is commonly used for relief from mild joint pain and inflammation.

Serrapeptase has also been shown to break down and dissolve biofilms, and can support healthy, balanced gut flora.

Serrapeptase is easily destroyed and deactivated by your stomach acid. The serrapeptase in SerraDefend is enteric-coated to ensure this doesn’t happen.


This is a fibrinolytic systemic enzyme that promotes normal healing and repair in the human body. It is most commonly used to promote healthy circulation.

Nattokinase can also assist your body in breaking down biofilms and supporting healthy digestion.


This is an enzyme that breaks down chitosan, a key building block in yeast cell walls. Chitosanase has the unique ability to break down these yeast cell walls by helping your body to dissolve the chitosan.


Beta-glucanase is an enzyme that breaks down the glycosidic bonds within beta-glucans. These glucans form up to 60% of the cell walls and biofilms of many microorganisms, include Candida yeast cells. Beta-glucanase has been scientifically proven to disrupt biofilm formation.


Cellulase is one of the only digestive enzymes that your body does not produce by itself, so you need to get it from food or supplements. Cellulase allows your body to more efficiently break down cellulose in yeast cell walls, and it has also been shown to inhibit biofilm formation.


This is an enzyme that breaks down substances closely related to cellulase, like galactans, xylans, mannans, and arabans, which are also components of yeast cell walls.


Amylase is a digestive enzyme that assists your body in breaking down starches. It is naturally present in your saliva, promotes healthy digestion of carbohydrates, and has been shown to inhibit biofilm formation in yeast and other microorganisms.


Glucoamylase is another digestive enzyme that helps us to break down starches, in this case the glucosidic linkages that hold the starches together. It can assist in healthy digestion and help to relieve digestive upset.


Proteases are a group of enzymes that help to break down proteins and promote healthy digestion. In the gut, they break down proteins into amino acids that are easily absorbed and play many critical roles in your body.

How To Take SerraDefend

To get the most out of these systemic and digestive enzymes, try the following tips:

  • Take one capsule per day
    Each easy-to-swallow capsule contains a powerful dose of the 9 systemic and digestive enzymes
  • Take SerraDefend away from food
    To get the most anti-inflammatory and biofilm-busting benefit from SerraDefend, take it at least 30 minutes away from a meal.
  • It works well with probiotics and antifungals
    You can take SerraDefend if you are already taking a probiotic and antifungal. The probiotic and antifungal are generally taken with food, while SerraDefend is taken between meals.

9 Biofilm-Busting Enzymes In One Supplement

As you can see, there are a number of systemic and digestive enzymes that have biofilm-busting capabilities.

It’s not easy to take all of these enzymes together, which is why we designed a formula that includes them all in one package.

Here are a few key characteristics of SerraDefend:

  • Two systemic enzymes to break Candida biofilms: Serrapeptase and Nattokinase
  • Seven digestive enzymes to inhibit Candida overgrowth and support healthy digestion:
    Chitosanase, Beta-glucanase, Protease, Cellulase, Hemicellulase, Amylase, and Glucoamylase.
  • 60 capsules per bottle (enough for 2 months)
  • Made in the USA in our cGMP-certified facility.
  • Free of nuts, dairy, gluten, soy. Non-GMO and vegan. No preservatives or artificial colors

SerraDefend is our preferred combination enzyme formula for Candida.

You can find SerraDefend on the Balance ONE website.

It’s the only multi-enzyme formula that contains significant amounts of each of these Candida-fighting enzymes.

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3-Month Candida Elimination Kit Start Your 3-month Candida Cleanse

This Candida Kit contains all the supplements recommended on the Candida Diet:
LIVER ONE to process and remove the toxins created by Candida.
CANDASSIST to inhibit and weaken the Candida colonies in your gut.
PROBIOTIC to replace the Candida yeast with probiotic bacteria.
Plus… the CANDIDA DIET RECIPE BOOK with 50+ low-sugar recipes

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